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Suppressive effects of antiandrogens, finasteride and flutamide on development of prostatic lesions in a transgenic rat model.

Cho YM, Takahashi S, Asamoto M, Suzuki S, Tang M, Shirai T

1Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya, Japan.

Transgenic (TG) rats bearing a probasin promoter/simian virus 40 T antigen (SV40 Tag) construct were treated with antiandrogens to examine their ability to suppress prostate carcinogenesis. Finasteride and flutamide were administered to 10-week-old TG rats five times a week for 2, 5 and 7 weeks. Antiandrogen-treated prostates exhibited atrophic glandular structures with almost no expression of SV40 Tag and only weak signals for androgen receptors. Furthermore, quantitative data for ventral prostate adenocarcinomas showed significant decrease with antiandrogen treatment. Both finasteride and flutamide had the ability to suppress SV40 Tag-driven carcinogenesis through their different antiandrogenic mechanisms, suggesting that this TG model is suitable for exploring the potential of agents to inhibit prostate cancer development.Prostate Cancer and Prostatic Diseases advance online publication, 24 April 2007; doi:10.1038/sj.pcan.4500971.

Published 25 April 2007 in Prostate Cancer Prostatic Dis.
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